Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.
Identifieur interne : 000758 ( Main/Exploration ); précédent : 000757; suivant : 000759Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.
Auteurs : Tae-Kyeong Lee [Corée du Sud] ; Joon Ha Park [Corée du Sud] ; Ji Hyeon Ahn [Corée du Sud] ; Hyunjung Kim [Corée du Sud] ; Minah Song [Corée du Sud] ; Jae-Chul Lee [Corée du Sud] ; Jong Dai Kim [Corée du Sud] ; Yong Hwan Jeon [Corée du Sud] ; Jung Hoon Choi [Corée du Sud] ; Choong Hyun Lee [Corée du Sud] ; In Koo Hwang [Corée du Sud] ; Bing-Chun Yan [République populaire de Chine] ; Moo-Ho Won [Corée du Sud] ; Il Jun Kang [Corée du Sud]Source :
- Chinese journal of natural medicines [ 1875-5364 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Cellules pyramidales (effets des médicaments et des substances chimiques), Cellules pyramidales (métabolisme), Extraits de plantes (administration et posologie), Facteur de croissance IGF-I (génétique), Facteur de croissance IGF-I (métabolisme), Facteur neurotrophique dérivé du cerveau (génétique), Facteur neurotrophique dérivé du cerveau (métabolisme), Gerbillinae (MeSH), Humains (MeSH), Lésion d'ischémie-reperfusion (génétique), Lésion d'ischémie-reperfusion (métabolisme), Lésion d'ischémie-reperfusion (traitement médicamenteux), Mâle (MeSH), Neuroprotecteurs (administration et posologie), Populus (composition chimique), Région CA1 de l'hippocampe (effets des médicaments et des substances chimiques), Région CA1 de l'hippocampe (métabolisme), Régulation positive (effets des médicaments et des substances chimiques), Superoxide dismutase (génétique), Superoxide dismutase (métabolisme).
- MESH :
- administration et posologie : Extraits de plantes, Neuroprotecteurs.
- composition chimique : Populus.
- effets des médicaments et des substances chimiques : Cellules pyramidales, Région CA1 de l'hippocampe, Régulation positive.
- génétique : Facteur de croissance IGF-I, Facteur neurotrophique dérivé du cerveau, Lésion d'ischémie-reperfusion, Superoxide dismutase.
- métabolisme : Cellules pyramidales, Facteur de croissance IGF-I, Facteur neurotrophique dérivé du cerveau, Lésion d'ischémie-reperfusion, Région CA1 de l'hippocampe, Superoxide dismutase.
- traitement médicamenteux : Lésion d'ischémie-reperfusion.
- Animaux, Gerbillinae, Humains, Mâle.
English descriptors
- KwdEn :
- Animals (MeSH), Brain-Derived Neurotrophic Factor (genetics), Brain-Derived Neurotrophic Factor (metabolism), CA1 Region, Hippocampal (drug effects), CA1 Region, Hippocampal (metabolism), Gerbillinae (MeSH), Humans (MeSH), Insulin-Like Growth Factor I (genetics), Insulin-Like Growth Factor I (metabolism), Male (MeSH), Neuroprotective Agents (administration & dosage), Plant Extracts (administration & dosage), Populus (chemistry), Pyramidal Cells (drug effects), Pyramidal Cells (metabolism), Reperfusion Injury (drug therapy), Reperfusion Injury (genetics), Reperfusion Injury (metabolism), Superoxide Dismutase (genetics), Superoxide Dismutase (metabolism), Up-Regulation (drug effects).
- MESH :
- chemical , administration & dosage : Neuroprotective Agents, Plant Extracts.
- chemical , genetics : Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor I, Superoxide Dismutase.
- chemical , metabolism : Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor I, Superoxide Dismutase.
- chemistry : Populus.
- drug effects : CA1 Region, Hippocampal, Pyramidal Cells, Up-Regulation.
- drug therapy : Reperfusion Injury.
- genetics : Reperfusion Injury.
- metabolism : CA1 Region, Hippocampal, Pyramidal Cells, Reperfusion Injury.
- Animals, Gerbillinae, Humans, Male.
Abstract
To examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia (TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries for 5 min. Before ischemic surgery, 200 mg·kg-1 PT extract was orally administrated once daily for 7 d. We performed neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B staining. Furthermore, we determined in situ production of superoxide anion radical, expression levels of SOD1 and SOD2 as antioxidant enzymes and brain-derived neurotrophic factor (BDNF) and insulin-like growth factor I (IGF-I) as neurotrophic factors. Pretreatment with 200 mg·kg-1 PT extract prevented neuronal death (loss). Furthermore, pretreatment with 200 mg·kg-1 PT extract significantly inhibited the production of superoxide anion radical, increased expressions of SODs and maintained expressions of BDNF and IGF-I. Such increased expressions of SODs were maintained in the neurons after IRI. In summary, pretreated PT extract can significantly increase levels of SODs and protect the neurons against TGCI, suggesting that PT can be a useful natural agent to protect against TGCI.
DOI: 10.1016/S1875-5364(19)30050-0
PubMed: 31262455
Affiliations:
- Corée du Sud, République populaire de Chine
- Région capitale de Séoul
- Séoul
- Université nationale de Séoul
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In Koo" sort="Hwang, In Koo" uniqKey="Hwang I" first="In Koo" last="Hwang">In Koo Hwang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Yan, Bing Chun" sort="Yan, Bing Chun" uniqKey="Yan B" first="Bing-Chun" last="Yan">Bing-Chun Yan</name><affiliation wicri:level="1"><nlm:affiliation>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001</wicri:regionArea><wicri:noRegion>Yangzhou 225001</wicri:noRegion></affiliation></author><author><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: mhwon@kangwon.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address: ijkang@hallym.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252</wicri:regionArea><wicri:noRegion>Chuncheon 24252</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31262455</idno><idno type="pmid">31262455</idno><idno type="doi">10.1016/S1875-5364(19)30050-0</idno><idno type="wicri:Area/Main/Corpus">000814</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000814</idno><idno type="wicri:Area/Main/Curation">000814</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000814</idno><idno type="wicri:Area/Main/Exploration">000814</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.</title><author><name sortKey="Lee, Tae Kyeong" sort="Lee, Tae Kyeong" uniqKey="Lee T" first="Tae-Kyeong" last="Lee">Tae-Kyeong Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Park, Joon Ha" sort="Park, Joon Ha" uniqKey="Park J" first="Joon Ha" last="Park">Joon Ha Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252</wicri:regionArea><wicri:noRegion>Chuncheon 24252</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Ji Hyeon" sort="Ahn, Ji Hyeon" uniqKey="Ahn J" first="Ji Hyeon" last="Ahn">Ji Hyeon Ahn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252</wicri:regionArea><wicri:noRegion>Chuncheon 24252</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hyunjung" sort="Kim, Hyunjung" uniqKey="Kim H" first="Hyunjung" last="Kim">Hyunjung Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Song, Minah" sort="Song, Minah" uniqKey="Song M" first="Minah" last="Song">Minah Song</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Chul" sort="Lee, Jae Chul" uniqKey="Lee J" first="Jae-Chul" last="Lee">Jae-Chul Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jong Dai" sort="Kim, Jong Dai" uniqKey="Kim J" first="Jong Dai" last="Kim">Jong Dai Kim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Jeon, Yong Hwan" sort="Jeon, Yong Hwan" uniqKey="Jeon Y" first="Yong Hwan" last="Jeon">Yong Hwan Jeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, School of Medicine, Kangwon National University, Chuncheon 24289, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, School of Medicine, Kangwon National University, Chuncheon 24289</wicri:regionArea><wicri:noRegion>Chuncheon 24289</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Jung Hoon" sort="Choi, Jung Hoon" uniqKey="Choi J" first="Jung Hoon" last="Choi">Jung Hoon Choi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Choong Hyun" sort="Lee, Choong Hyun" uniqKey="Lee C" first="Choong Hyun" last="Lee">Choong Hyun Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116</wicri:regionArea><wicri:noRegion>Cheonan 31116</wicri:noRegion></affiliation></author><author><name sortKey="Hwang, In Koo" sort="Hwang, In Koo" uniqKey="Hwang I" first="In Koo" last="Hwang">In Koo Hwang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Yan, Bing Chun" sort="Yan, Bing Chun" uniqKey="Yan B" first="Bing-Chun" last="Yan">Bing-Chun Yan</name><affiliation wicri:level="1"><nlm:affiliation>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001</wicri:regionArea><wicri:noRegion>Yangzhou 225001</wicri:noRegion></affiliation></author><author><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: mhwon@kangwon.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address: ijkang@hallym.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252</wicri:regionArea><wicri:noRegion>Chuncheon 24252</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chinese journal of natural medicines</title><idno type="eISSN">1875-5364</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Brain-Derived Neurotrophic Factor (genetics)</term><term>Brain-Derived Neurotrophic Factor (metabolism)</term><term>CA1 Region, Hippocampal (drug effects)</term><term>CA1 Region, Hippocampal (metabolism)</term><term>Gerbillinae (MeSH)</term><term>Humans (MeSH)</term><term>Insulin-Like Growth Factor I (genetics)</term><term>Insulin-Like Growth Factor I (metabolism)</term><term>Male (MeSH)</term><term>Neuroprotective Agents (administration & dosage)</term><term>Plant Extracts (administration & dosage)</term><term>Populus (chemistry)</term><term>Pyramidal Cells (drug effects)</term><term>Pyramidal Cells (metabolism)</term><term>Reperfusion Injury (drug therapy)</term><term>Reperfusion Injury (genetics)</term><term>Reperfusion Injury (metabolism)</term><term>Superoxide Dismutase (genetics)</term><term>Superoxide Dismutase (metabolism)</term><term>Up-Regulation (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Cellules pyramidales (effets des médicaments et des substances chimiques)</term><term>Cellules pyramidales (métabolisme)</term><term>Extraits de plantes (administration et posologie)</term><term>Facteur de croissance IGF-I (génétique)</term><term>Facteur de croissance IGF-I (métabolisme)</term><term>Facteur neurotrophique dérivé du cerveau (génétique)</term><term>Facteur neurotrophique dérivé du cerveau (métabolisme)</term><term>Gerbillinae (MeSH)</term><term>Humains (MeSH)</term><term>Lésion d'ischémie-reperfusion (génétique)</term><term>Lésion d'ischémie-reperfusion (métabolisme)</term><term>Lésion d'ischémie-reperfusion (traitement médicamenteux)</term><term>Mâle (MeSH)</term><term>Neuroprotecteurs (administration et posologie)</term><term>Populus (composition chimique)</term><term>Région CA1 de l'hippocampe (effets des médicaments et des substances chimiques)</term><term>Région CA1 de l'hippocampe (métabolisme)</term><term>Régulation positive (effets des médicaments et des substances chimiques)</term><term>Superoxide dismutase (génétique)</term><term>Superoxide dismutase (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Neuroprotective Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term><term>Insulin-Like Growth Factor I</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term><term>Insulin-Like Growth Factor I</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Extraits de plantes</term><term>Neuroprotecteurs</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>CA1 Region, Hippocampal</term><term>Pyramidal Cells</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Reperfusion Injury</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cellules pyramidales</term><term>Région CA1 de l'hippocampe</term><term>Régulation positive</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Reperfusion Injury</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance IGF-I</term><term>Facteur neurotrophique dérivé du cerveau</term><term>Lésion d'ischémie-reperfusion</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CA1 Region, Hippocampal</term><term>Pyramidal Cells</term><term>Reperfusion Injury</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules pyramidales</term><term>Facteur de croissance IGF-I</term><term>Facteur neurotrophique dérivé du cerveau</term><term>Lésion d'ischémie-reperfusion</term><term>Région CA1 de l'hippocampe</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lésion d'ischémie-reperfusion</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gerbillinae</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Gerbillinae</term><term>Humains</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia (TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries for 5 min. Before ischemic surgery, 200 mg·kg<sup>-1</sup> PT extract was orally administrated once daily for 7 d. We performed neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B staining. Furthermore, we determined in situ production of superoxide anion radical, expression levels of SOD1 and SOD2 as antioxidant enzymes and brain-derived neurotrophic factor (BDNF) and insulin-like growth factor I (IGF-I) as neurotrophic factors. Pretreatment with 200 mg·kg<sup>-1</sup> PT extract prevented neuronal death (loss). Furthermore, pretreatment with 200 mg·kg<sup>-1</sup> PT extract significantly inhibited the production of superoxide anion radical, increased expressions of SODs and maintained expressions of BDNF and IGF-I. Such increased expressions of SODs were maintained in the neurons after IRI. In summary, pretreated PT extract can significantly increase levels of SODs and protect the neurons against TGCI, suggesting that PT can be a useful natural agent to protect against TGCI.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31262455</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>03</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-5364</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Chinese journal of natural medicines</Title><ISOAbbreviation>Chin J Nat Med</ISOAbbreviation></Journal><ArticleTitle>Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.</ArticleTitle><Pagination><MedlinePgn>424-434</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1875-5364(19)30050-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1875-5364(19)30050-0</ELocationID><Abstract><AbstractText>To examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia (TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries for 5 min. Before ischemic surgery, 200 mg·kg<sup>-1</sup> PT extract was orally administrated once daily for 7 d. We performed neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B staining. Furthermore, we determined in situ production of superoxide anion radical, expression levels of SOD1 and SOD2 as antioxidant enzymes and brain-derived neurotrophic factor (BDNF) and insulin-like growth factor I (IGF-I) as neurotrophic factors. Pretreatment with 200 mg·kg<sup>-1</sup> PT extract prevented neuronal death (loss). Furthermore, pretreatment with 200 mg·kg<sup>-1</sup> PT extract significantly inhibited the production of superoxide anion radical, increased expressions of SODs and maintained expressions of BDNF and IGF-I. Such increased expressions of SODs were maintained in the neurons after IRI. In summary, pretreated PT extract can significantly increase levels of SODs and protect the neurons against TGCI, suggesting that PT can be a useful natural agent to protect against TGCI.</AbstractText><CopyrightInformation>Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Tae-Kyeong</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Joon Ha</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahn</LastName><ForeName>Ji Hyeon</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hyunjung</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Minah</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jae-Chul</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jong Dai</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Yong Hwan</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Radiology, School of Medicine, Kangwon National University, Chuncheon 24289, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Jung Hoon</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Choong Hyun</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>In Koo</ForeName><Initials>IK</Initials><AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Bing-Chun</ForeName><Initials>BC</Initials><AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Won</LastName><ForeName>Moo-Ho</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: mhwon@kangwon.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Il Jun</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address: ijkang@hallym.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Chin J Nat Med</MedlineTA><NlmUniqueID>101504416</NlmUniqueID><ISSNLinking>1875-5364</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018696">Neuroprotective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>67763-96-6</RegistryNumber><NameOfSubstance UI="D007334">Insulin-Like Growth Factor I</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019208" MajorTopicYN="N">Brain-Derived Neurotrophic Factor</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056547" MajorTopicYN="N">CA1 Region, Hippocampal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005849" MajorTopicYN="N">Gerbillinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007334" MajorTopicYN="N">Insulin-Like Growth Factor I</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018696" MajorTopicYN="N">Neuroprotective Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017966" MajorTopicYN="N">Pyramidal Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015427" MajorTopicYN="N">Reperfusion Injury</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidant enzymes</Keyword><Keyword MajorTopicYN="N">Neuroprotective effects</Keyword><Keyword MajorTopicYN="N">Populus tomentiglandulosa</Keyword><Keyword MajorTopicYN="N">Transient global cerebral ischemia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>02</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31262455</ArticleId><ArticleId IdType="pii">S1875-5364(19)30050-0</ArticleId><ArticleId IdType="doi">10.1016/S1875-5364(19)30050-0</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>République populaire de Chine</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Lee, Tae Kyeong" sort="Lee, Tae Kyeong" uniqKey="Lee T" first="Tae-Kyeong" last="Lee">Tae-Kyeong Lee</name></noRegion><name sortKey="Ahn, Ji Hyeon" sort="Ahn, Ji Hyeon" uniqKey="Ahn J" first="Ji Hyeon" last="Ahn">Ji Hyeon Ahn</name><name sortKey="Choi, Jung Hoon" sort="Choi, Jung Hoon" uniqKey="Choi J" first="Jung Hoon" last="Choi">Jung Hoon Choi</name><name sortKey="Hwang, In Koo" sort="Hwang, In Koo" uniqKey="Hwang I" first="In Koo" last="Hwang">In Koo Hwang</name><name sortKey="Jeon, Yong Hwan" sort="Jeon, Yong Hwan" uniqKey="Jeon Y" first="Yong Hwan" last="Jeon">Yong Hwan Jeon</name><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><name sortKey="Kim, Hyunjung" sort="Kim, Hyunjung" uniqKey="Kim H" first="Hyunjung" last="Kim">Hyunjung Kim</name><name sortKey="Kim, Jong Dai" sort="Kim, Jong Dai" uniqKey="Kim J" first="Jong Dai" last="Kim">Jong Dai Kim</name><name sortKey="Lee, Choong Hyun" sort="Lee, Choong Hyun" uniqKey="Lee C" first="Choong Hyun" last="Lee">Choong Hyun Lee</name><name sortKey="Lee, Jae Chul" sort="Lee, Jae Chul" uniqKey="Lee J" first="Jae-Chul" last="Lee">Jae-Chul Lee</name><name sortKey="Park, Joon Ha" sort="Park, Joon Ha" uniqKey="Park J" first="Joon Ha" last="Park">Joon Ha Park</name><name sortKey="Song, Minah" sort="Song, Minah" uniqKey="Song M" first="Minah" last="Song">Minah Song</name><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Yan, Bing Chun" sort="Yan, Bing Chun" uniqKey="Yan B" first="Bing-Chun" last="Yan">Bing-Chun Yan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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